hypertrophic cardiomyopathy pathophysiology ppt

CARDIOMYOPATHY BY: RICHARD KAMINSKI DESCRIPTION OF DISEASE • Hypertrophic cardiomyopathy (HCM) occurs if heart muscle cells enlarge and cause the walls of the ventricles (usually the left ventricle) to thicken. Hypertrophic cardiomyopathy (HCM) (see the image below) is a genetic disorder that is typically inherited in an autosomal dominant fashion with variable penetrance and variable expressivity. Ommen, SR et al. At the present stage of development of our knowledge, enough data has accumulated, suggesting that hypertrophic cardiomyopathy is a hereditary disease transmitted by an autosomal dominant type with various penetrance and expressiveness. Circulation. The thickened heart muscle can make it harder for the heart to pump blood.Hypertrophic cardiomyopathy often goes undiagnosed because many people with the disease have few, if any, symptoms and can lead normal lives with no significant problems. Many of them are also animated. Evaluation and Testing for HCM. MAIN TYPES OF CARDIOMYOPATHY Hypertrophic Cardiomyopathy: Hypertrophy means ‘increase in size.’ It is the increase in size of the heart muscle. What Causes Hypertrophic Cardiomyopathy? Hypertrophic Cardiomyopathy Dr. Fuad Farooq Resident CardiologyAga Khan University Hospital 2. Hypertrophic cardiomyopathy (HCM) is a genetic disorder of cardiac myocytes that is characterized by cardiac hypertrophy, unexplained by the loading conditions; a nondilated left ventricle; and a normal or increased ejection fraction. Introduction. Causes of sudden cardiac death in young people Myocarditis 3% Maron BJ et al. You can change your ad preferences anytime. Slideshare uses cookies to improve functionality and performance, and to provide you with relevant advertising. Aetiology. See our User Agreement and Privacy Policy. Powerpoint slides. The ventricle size often remains normal, but the thickening may block blood flow out of the ventricle. Whether your application is business, how-to, education, medicine, school, church, sales, marketing, online training or just for fun, PowerShow.com is a great resource. Early Detection of Hypertrophic Cardiomyopathy, - Title: Slide 1 Author: mwiegand Last modified by: June Hanks Created Date: 4/15/2008 10:37:56 PM Document presentation format: On-screen Show (4:3) Company. - Cardiomyopathy is a serious condition of the heart, in which the heart muscles become inflamed and weakened. This scarring leads to progressive thinning of the septum  outflow tract enlargement (mimicking LV remodeling that occurs after myectomy). Circulation. The two patients thought to be in cardiogenic shock were given inotropes … Hypertrophic cardiomyopathy (HCM) is a disorder of the myocardium caused by mutations of the sarcomere or sarcomere-associated proteins. Colors correspond to the Class of Recommendation DISCUSSION: Hypertrophic cardiomyopathy(HCM) is a condition of the heart characterized by the thickening of the interventricular septum. It is commonly asymmetrical with the most severe hypertrophy involving the basal interventricular septum. Hypertrophic cardiomyopathy (HCM) is a heterogeneous genetic heart muscle disease affecting 1 of every 500 persons (1, 2).Individuals with HCM are at an increased risk of heart failure and sudden cardiac death ().Usually, HCM is characterized by cardiac hypertrophy with preserved or increased ejection fraction (EF) and cardiac contractility in the absence of secondary causes. Alcohol septal ablation. CrystalGraphics 3D Character Slides for PowerPoint, - CrystalGraphics 3D Character Slides for PowerPoint. Aetiology. Cardiomyopathy is any structural and functional abnormality of the heart muscle unattributable to specific causes or disease processes such as coronary artery disease (CAD), congenital heart disease, or valvular disease. Over the years, classification of this condition has been updated by the rapid advancement of genetic, imaging, and clinical investigation. A J Marian (Jan 1, p 58)1 postulates that cardiac contractility is decreased in hypertrophic cardiomyopathy (HCM) and that the preserved or increased ejection fraction observed in patients with HCM is a result of the concentric nature of the hypertrophy. Long-term Hypertension B. Aortic Stenosis C. Myocardial Ischemia D. Familial and Genetic, Hypertrophic Cardiomyopathy (HCM) Therapeutics Market Analysis by Demand, Trend, Revenue, Market Segment & Forecast to 2023. Five patients, all women, age ranges 59 to 84 years, with underlying hypertrophic obstructive cardiomyopathy (HOCM) presented with profound hypotension. The Global Therapeutic Landscape of Hypertrophic Cardiomyopathy. Hypertrophic cardiomyopathy. Colors correspond to the Class of Recommendation - The report provides comprehensive information on the therapeutics under development for Hypertrophic Cardiomyopathy, complete with analysis by stage of development, drug target, mechanism of action (MoA), route of administration (RoA) and molecule type. And, best of all, most of its cool features are free and easy to use. Hypertrophic Cardiomyopathy ; various degree of hypertrophy ; various degree of obstruction ; various age at presentation ; various mortality risk; 15 Hypertrophic Cardiomyopathy. D. Aortic stenosis. Hypertrophic cardiomyopathy (HCM) is the most common inherited cardiovascular disorder, representing a leading cause of sudden cardiac death in the young and a prevalent cause of heart failure and stroke. Heart 2010; 96(20):1669-75 [8] Richard P, Charron P, ... | PowerPoint PPT presentation | free to view, Global Hypertrophic Cardiomyopathy (HCM) Therapeutics Market Insight and Forecast to 2026. Classification and Definitions of Cardiomyopathies 9 3.1. Cardiomyopathies are diseases of the muscle tissue of the heart.Types of cardiomyopathies include dilated, hypertrophic, restrictive, and arrhythmogenic right ventricular cardiomyopathy. XXX:XX-XX. Circulation. Sato H, TateishiH, Uchida T, et al. 1,2 It has a prevalence of 1 in 500 within the general population, and is a known cause of sudden cardiac death. In other instances, the cause is unknown. It mainly manifests as symmetric or asymmetric left ventricular hypertrophy (LVH) > 1.5 cm (Figure 23–1) in a nondilated ventricle unexplained by other cardiac or systemic causes of hypertrophy (see Table 23–1 for differential diagnosis of LVH). - Hypertrophic Cardiomyopathy (HCM) Therapeutics market report provides a brief and detailed knowledge of key reports, market conditions and circumstances. Interrelations of clinical manifestations, pathophysiology and therapy (2). Atrial fibrillation (AF) is frequently associated with HCM with a reported prevalence of about 20% to 25%. N Engl J Med. 1996;94:850-56. Do you have PowerPoint slides to share? 22: Figure 1. Dilated cardiomyopathy is the most common type of cardiomyopathy.Although most cases are idiopathic, a number of conditions (e.g., coronary artery disease, wet beriberi), infections … INHibition of the renin angiotensin system in hypertrophic cardiomyopathy and the Effect on hypertrophy, - INHibition of the renin angiotensin system in hypertrophic cardiomyopathy and the Effect on hypertrophy a Randomized Intervention Trial with losartan. It is commonly asymmetrical … 1. If so, share your PPT presentation slides online with PowerShow.com. Hypertrophic cardiomyopathy (HCM) is the most common monogenic cardiovascular disorder, affecting one of every 500 adults.It is found across all racial groups and is the most common cause of sudden death in young athletes ().The disease is characterized by left ventricular (LV) hypertrophy in the absence of another systemic or cardiac disease to account for the changes noted. In 2010, the Study Group on peripartum cardiomyopathy of the Heart Failure Association (HFA) of the European Society of Cardiology (ESC) defined PPCM as an idiopathic cardiomyopathy occurring towards the end of pregnancy or in the months following delivery, abortion or miscarriage, without other causes for heart failure, and with a left ventricular (LV) ejection fraction (EF) < 45% 5 (see Box). The PowerPoint PPT presentation: "Hypertrophic Cardiomyopathy" is the property of its rightful owner. Hypertrophic cardiomyopathy (HCM) is a disorder of the myocardium caused by mutations of the sarcomere or sarcomere-associated proteins. The disease has complex symptomatology and potentially devastating consequences for … Spirito, P. et al. - Hypertrophic cardiomyopathy Frank and Mehta Non-Surgical Septal Ablation Echocardiographic still frames (systole) from the parasternal long-axis. What Causes Hypertrophic Cardiomyopathy? Hypertrophic cardiomyopathy (36%) Aortic stenosis 4% Congenital coronary anomalies (19%) Mildly increased cardiac mass (10%) Ruptured aorta … Our new CrystalGraphics Chart and Diagram Slides for PowerPoint is a collection of over 1000 impressively designed data-driven chart and editable diagram s guaranteed to impress any audience. 2020 ACC/AHA Guideline for the Diagnosis and Treatment of Patients with Hypertrophic Cardiomyopathy. Summary. They'll give your presentations a professional, memorable appearance - the kind of sophisticated look that today's audiences expect. The base year considered for the study is 2019, and the market size is projected from 2020 to 2026. This results in the heart being less able to pump blood effectively and also may cause electrical conduction problems.. People who have HCM may have a range of symptoms. Genetic Etiology of Hypertrophic Cardiomyopathy (HCM) ~30-60% of HCM patients have an identifiable pathogenic or likely-pathogenic genetic variant Many others have no genetic evidence of disease and / or 2,3 Recognised autosomal dominant mutations within sarcomere proteins are found in 55 % of adolescents with sporadic HCM. In 2010, the Study Group on peripartum cardiomyopathy of the Heart Failure Association (HFA) of the European Society of Cardiology (ESC) defined PPCM as an idiopathic cardiomyopathy occurring towards the end of pregnancy or in the months following delivery, abortion or miscarriage, without other causes for heart failure, and with a left ventricular (LV) ejection fraction (EF) < 45% 5 (see Box). Hypertrophic cardiomyopathy (HCM) is a genetically determined heart muscle disease most often (60 to 70 percent) caused by mutations in one of several sarcomere genes which encode components of the contractile apparatus of the heart. Cardiology Grand Rounds from the University of Texas Medical Branch Hypertrophic Cardiomyopathy: Presentation and Pathophysiology Marschall S. Runge, MD George A. Stouffer, MD * Richard G. Sheahan, MD Stamatios Lerakis, MD From the Division of Cardiology, Department of Medicine, The University of Texas Medical Branch, Galveston, Texas. - Myocyte 'disarray' 2/2 sarcomere mutations causes LV hypertrophy, usually with ... hypertrophic subaortic stenosis) and ASH (Asymmetric septal hypertrophy) are ... - Hypertrophic Cardiomyopathy Board Review Rami Khouzam, MD Hypertrophic Cardiomyopathy Definition: WHO: left and/or right ventricular hypertrophy, usually asymmetric ... Heart Muscle Disease (Cardiomyopathy) (1). Hypertrophic cardiomyopathy (HCM) is a common genetic cardiac disorder, with an autosomal dominant mechanism of inheritance. Hypertrophic cardiomyopathy (HCM) is a genetic disorder that is characterized by left ventricular hypertrophy unexplained by secondary causes and a nondilated left ventricle with preserved or increased ejection fraction. Hypertrophic cardiomyopathy 1. Causes of sudden cardiac death in young people Myocarditis 3% Maron BJ et al. Hypertrophic cardiomyopathy (HCM) is a primary and usually familial cardiac disorder with heterogeneous expression, unique pathophysiology, and a diverse clinical course, for which several disease-causing mutations in genes encoding proteins of the sarcomere have been reported.1–7 Because of the characteristic clinical, morphological, and genetic diversity, HCM has held the curiosity … Primary cardiomyopathies 3.1.1 Genetic 3.1.1.1 Hypertrophic cardiomyopathy HCM is a condition of the heart in which a part of the myocardium or the muscle of the However, in a small number of people wi… Takotsubotype cardiomyopathy due to multivesselspasm. Retrospective trial by a group at the Mayo Clinic Aim: Long-term effects of myectomy on survival Looked at mortality retrospectively among 3 groups from 1983-2001: 1) myectomy 2) LVOT obstruction w/o surgery 3) Non-obstructive HCM Mean follow-up: 6 yrs Compared to non-operative obstructive, myectomy patients had superior survival free from all-cause mortality / HCM-related mortality / sudden cardiac death. Case17 years old male professional basketball player with noknown past medical history collapses on the playing floorduring practice and subsequently arrests. And they’re ready for you to use in your PowerPoint presentations the moment you need them. Now customize the name of a clipboard to store your clips. The report also covers the descriptive pharmacological action … Boasting an impressive range of designs, they will support your presentations with inspiring background photos or videos that support your themes, set the right mood, enhance your credibility and inspire your audiences. A catheter is inserted into the LAD and directed into the septal branch that supplies blood to the hypertrophied portion of the septum. Hypertrophic cardiomyopathy (HCM) is a condition in which the heart becomes thickened without an obvious cause. the diagnosis, characterize the pathophysiology for the individual, and identify risk markers that may inform decisions regarding interventions ... *HCM indicates hypertrophic cardiomyopathy . The parts of the heart most commonly affected are the interventricular septum and the ventricles. Pathophysiology Hypertrophic cardiomyopathy (HCM) is the most common monogenic cardiovascular disorder, affecting one of every 500 adults.It is found across all racial groups and is the most common cause of sudden death in young athletes ().The disease is characterized by left ventricular (LV) hypertrophy in the absence of another systemic or cardiac disease to account for the changes noted. REFERENCES. Up to 60% of the cases are due to mutations in HYPERTROPHIC. We use your LinkedIn profile and activity data to personalize ads and to show you more relevant ads. Initial clinical and hemodynamic evaluation suggested cardiogenic shock in two cases, acute myocardial ischemia in two cases, and hypovolemia in one case. Hypertrophic cardiomyopathy (HCM) is defined as a primary cardiac muscle hypertrophy of the left ventricle in the absence of other structural or functional abnormality. Hypertrophic Cardiomyopathy. Introduction. It is occasionally restricted to other myocardial regions, such as the apex, the midportion, and the posterior wall of the left ventricle… Evaluation and Testing for HCM. Ommen, SR et al. TM, 54, WAS ADMITTED to the ED after a syncopal episode that resulted in a head injury. Hypertrophic cardiomyopathy Characterised by myocardial hypertrophy,abnormal diastolic filling,intermittent ventricular outflow obstruction Related to defects in force generation owing to altered sarcomeric function Leading cause of LVH,unexplained by other clinical/pathologic cause Caused by mutation of genes encoding sarcomeric proteins Hypertrophic cardiomyopathy (HCM) (see the image below) is a genetic disorder that is typically inherited in an autosomal dominant fashion with variable penetrance and variable expressivity. 1 It is typically inherited via autosomal dominant pattern with mutations in cardiac sarcomere protein genes. Or use it to create really cool photo slideshows - with 2D and 3D transitions, animation, and your choice of music - that you can share with your Facebook friends or Google+ circles. Hypertrophic cardiomyopathy (HCM) is the most common inherited cardiovascular disorder, representing a leading cause of sudden cardiac death in the young and a prevalent cause of heart failure and stroke. Slideshare uses cookies to improve functionality and performance, and to provide you with relevant advertising. The Global Therapeutic Landscape of Hypertrophic Cardiomyopathy - The report provides comprehensive information on the therapeutics under development for Hypertrophic Cardiomyopathy, complete with analysis by stage of development, drug target, mechanism of action (MoA), route of administration (RoA) and molecule type. Images. Vet Clin North Am Small Anim Pract 47 (5), 1041-1054 PubMed . 1996;94:850-56. Genetic Etiology of Hypertrophic Cardiomyopathy (HCM) ~30-60% of HCM patients have an identifiable pathogenic or likely-pathogenic genetic variant Many others have no genetic evidence of disease and / or Change in stress leads to adaptations. Hypertrophic cardiomyopathy (HCM) (see the image below) is a genetic disorder that is typically inherited in an autosomal dominant fashion with variable penetrance and variable expressivity. ... - Cardiomyopathy in neonates and children Dr Rajesh Kumar MD (PGI), DM (Neonatology) PGI, Chandigarh, India Rani Children Hospital, Ranchi Some cardiomyopathies are ... Clinical sensitivity of molecular genetic testing in hypertrophic cardiomyopathy. 16. INTRODUCTION. Takotsubotype cardiomyopathy due to multivesselspasm. HCM can run in families, but the condition may also be acquired as a part of aging or high blood pressure. - Beautifully designed chart and diagram s for PowerPoint with visually stunning graphics and animation effects. 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The two Patients thought to be in cardiogenic shock were given inotropes … What causes cardiomyopathy! 3 % Maron BJ et al if you continue browsing the site, you agree to the hypertrophied portion the... Ads and to show you more relevant ads 47 ( 5 ), 1041-1054.. ( 5 ), 1041-1054 PubMed old male professional basketball player with noknown medical... Admitted to the hypertrophied portion of the heart backwash of alcohol into the remainder of the becomes. These proteins, namely beta-myosin heavy chain, myosin-binding protein C and cardiac troponin C, are important! Of its rightful owner '' is the most severe hypertrophy involving the basal interventricular and. Sarcomere or sarcomere-associated proteins 2017 ) Asymptomative hypertrophic cardiomyopathy ( HCM ) is a condition! Animation effects Baxter S. use and interpretation of genetic, imaging, and the ventricles the of! All, most of its rightful owner structurally important in cardiac muscle to %. 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